The aim of the study was to create a new dosage form of naproxen -granules for rapid dissolution in the oral cavity, also to develop their optimum composition and drug formulation.Materials and Methods. The active ingredient: naproxen substance; excipients: lactose monohydrate, mannitol 100 SD (fillers), polyvinylpyrrolidone Kollidon CL (a disintegrant), sodium hydrogen carbonate and citric acid (gas-forming agent).Moisture-activated dry granulation with subsequent addition of citric acid was used to produce granules. Alcohol in different concentrations (5, 10, 20, and 30%) served as granulating liquid.Results. There has been developed the composition and drug manufacturing technology of the new dosage form of naproxengranules for rapid dissolution in the oral cavity. It has been established experimentally that granules obtained with the use of 20% alcohol have the most favorable technological characteristics. Quality assessment was carried out in accordance with the State Pharmacopoeia XIII.Conclusion. There has been obtained a new easy-to-use dosage form of naproxen with a high safety profile.