Aiming at the problems of low accuracy of recognition results, long recognition time, and easy interference in traditional methods, a deep learning-oriented recognition modeling method of college students' psychological stress indicators is proposed. First, the ECG signal is collected by the ECG signal acquisition system, and the wavelet transform method is used to denoise the collected ECG signal. Then, the sequential backward selection algorithm is used to select the features of psychological stress indicators to reduce the feature dimension. Finally, based on the convolutional neural network in deep learning technology, a mental pressure indicator recognition model is established and the model parameters are optimized to realize the recognition of college students’ mental pressure indicators. Experimental results show that the method in this paper has high recognition accuracy, has high recognition efficiency, is not susceptible to interference, and has certain feasibility and effectiveness.