DILI in China has a different etiology from that in Europe and USA. NSAIDs, which are the most common causes of DILI in western populations, are uncommon in China. Therefore, government, physicians, and patients should pay more attention to these drugs in DILI.

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During cardiac surgery, the excessive or insufficient contact force between the tip of catheter and heart tissue will lead to the cardiac penetration or noneffective ablative lesion. Usually, the surgeon can only estimate the force at the distal end roughly from their experience by operating the catheter's proximal handle. In this paper, we design a fiber Bragg grating-based triaxial force sensor with parallel flexure hinges to sense the contact force. The proposed mechanism integrated with parallel flexure hinges is capable of achieving an excellent lateral and axial stiffness balance to guarantee the resolution at each direction with the same order of magnitude. The mathematical model is built to design a suitable stiffness configuration and validate the design reasonability. The model-based and model-free methods are adopted to decouple lateral and axial force components. Experimental results demonstrate that the developed 8 French size force sensor can successfully achieve the triaxial force prediction with <1 g resolution using both decoupling methods. And the model-free method can accomplish a higher accuracy with RMS error <1% of full scale of [-100 g, 100 g] along the lateral direction and [0 g, 100 g] along the axial compression direction.

Oil source and hydrocarbon migration are critical in the study of hydrocarbon accumulation. Under the complicated conditions of hydrocarbon accumulation, traditional organic geochemistry has its limitation. Therefore, the purpose of this study is to try a new way to investigate hydrocarbon accumulation and migration. The occurrence of trace elements in crude oil and their activation and migration were studied. The fingerprint of trace elements was discussed. Our results indicate that rare earth elements and transition metals could be used for study of oil-source under the complicated conditions of hydrocarbon accumulation and migration. V/Ni ratio was a specific indicator in tracing hydrocarbon migration pathway. Tarim Basin, a typical complex superimposed basin in west China was studied. The result indicated that crude oil from the Ordovician in Tazhong (central Tarim) low uplift was characterized by mixed sources. The contributions of individual sources differed from formation to formation and from block to block. The distribution of underground fluid was significantly controlled by large-scale strike-slip faults. Our study result is consistent with the knowledge of field geologists. Application of trace elements as indicators is an effective method to study hydrocarbon accumulation and migration.