Background. The aim of this study is to compare the effects of sevoflurane and propofol on one lung ventilation (OLV) induced ischemia-reperfusion injury (IRI) by determining the blood gas, ischemia-modified albumin (IMA), and malonyldialdehyde (MDA). Material and Methods. Forty-four patients undergoing thoracic surgery with OLV were randomized in two groups (sevoflurane Group S, propofol Group P). Anesthesia was inducted with thiopental and was maintained with 1–2.5% of sevoflurane within the 40/60% of O2/N2O mixture in Group S. In Group P anesthesia was inducted with propofol and was maintained with infusion of propofol and remifentanil. Hemodynamic records and blood samples were obtained before anesthesia induction (t 1), 1 min before two lung ventilation (t 2), 30 min after two lung ventilation (t 3), and postoperative sixth hours (t 4). Results. Heart rate at t 2 and t 3 in Group P was significantly lower than that in Group S. While there were no significant differences in terms of pH and pCO2, pO2 at t 2 and t 3 in Group S was significantly lower than that in Group P. IMA levels at t 4 in Group S were significantly lower than those in Group P. Conclusion. Sevoflurane may offer protection against IRI after OLV in thoracic surgery.

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Hereditary Angioedema is a hereditary disease caused by deficiency or loss of C1 inhibitor (C1-INH), with an autosomal dominant inheritance pattern and which may be potentially life threatening. The prevalence of the disease is considerably low. In this case report, a 31 years old woman who has applied to the hospital with an angioedema attack after odontotherapy and who had angioedema attacks for many years with abdominal symptoms in the forefront and as a consequence to whom laparotomy was applied 3 times, is discussed together with literature. Hereditary Angioedema must certainly be considered for patients who apply to hospital with localized angioedema and especially with symptoms relating to upper airway tract and treatment strategy must be determined urgently, because delay in treatment increases morbidity and affects life quality. Keywords: Hereditary, angioedema, type ΙΙ ÖzetHerediter Anjioödem, C1 İnhibitör (C1-INH) fonksiyon kaybı veya eksikliği ile ortaya çıkan, otozomal dominant geçişli ve potansiyel olarak yaşamı tehdit edebilen kalıtsal bir hastalıktır. Hastalığın prevelansı oldukça düşüktür. Bu olgu sunumunda uzun yıllardır abdominal semptomların ön planda olduğu, anjioödem atakları geçiren ve bu nedenle 3 kez laparotomi uygulanan, diş tedavisi sonrası anjioödem atağı ile başvuran 31 yaşında kadın hasta literatür eşliğinde tartışıldı. Lokalize anjioödemle ve özellikle üst havayolunu ilgilendiren semptomlarla başvuran hastalarda herediter anjioödem mutlaka akılda bulundurulmalı, acil tedavi stratejisi belirlenmelidir. Çünkü tedavideki gecikme morbiditeyi arttırır ve yaşam kalitesini olumsuz etkiler.

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