This study numerically investigated the influence of using the second row of a double-row deswirl vane as the inlet guide vane of the second stage on the performance of the first stage in a two-stage refrigeration centrifugal compressor. The working fluid was R134a, and the turbulence model was the Spalart-Allmaras model. The parameters discussed included the cutting position of the deswirl vane, the staggered angle of two rows of vane, and the rotation angle of the second row. The results showed that the performance of staggered angle 7.5 ∘ was better than that of 15 ∘ or 22.5 ∘ . When the staggered angle was 7.5 ∘ , the performance of cutting at 1/3 and 1/2 of the original deswirl vane length was slightly different from that of the original vane but obviously better than that of cutting at 2/3. When the staggered angle was 15 ∘ , the cutting position influenced the performance slightly. At a low flow rate prone to surge, when the second row at a staggered angle 7.5 ∘ cutting at the half of vane rotated 10 ∘ , the efficiency was reduced by only about 0.6%, and 10% of the swirl remained as the preswirl of the second stage, which is generally better than other designs.