Aims: To determine the effects of percutaneous coronary intervention (PCI) on cardiac perfusion, cardiac function, and quality of life in patients with chronic total occlusion (CTO) lesion in left anterior descending (LAD) coronary artery.Methods and Results: Patients (n=99) with CTO lesion in the LAD coronary artery who had successfully undergone PCI were divided into three groups based on the SPECT/CTCA fusion imaging: (a) no severe cardiac perfusion defects (n=9); (b) reversible cardiac perfusion defects (n=40); or (c) fixed cardiac perfusion defects (n=50). No statistical difference of perfusion abnormality was observed at 6 months and 1 year after PCI in group (a). In group (b), SPECT/CTCA fusion imaging demonstrated that cardiac perfusion abnormality was significantly decreased 6 month and 1 year after PCI. Left ventricular ejection fraction (LVEF) increased significantly at 6 months and 1 year follow up. Quality of life improved at 6 months and 1 year after PCI procedure. Moreover, patients in group (c) also benefited from PCI therapy: a decrease in cardiac perfusion abnormality, an increase in LVEF, and an improvement in quality of life. PCI of coronary arteries in addition to LAD did not significantly affect cardiac function and quality of life improvement in each group.Conclusions: PCI exerts functional and clinical benefits in patients with CTO lesion in LAD coronary artery, particularly in patients with reversible cardiac perfusion defects. SPECT/CTCA fusion imaging may serve as a useful tool to evaluate the outcomes of patients with CTO lesion in LAD coronary artery.

BackgroundWhen ascending to the high altitude, people living in low altitude areas will suffer from acute mountain sickness. The aim of this study is to test the hypothesis that whether an oxygen concentration membrane can be made and used to construct a new portable oxygen enrichment device for individuals in acute exposure to the high altitude.MethodsThe membrane was fabricated using vinylsiloxane rubber, polyphenylene oxide hydrogen silicone polymers, chloroplatinic acid and isopropyl alcohol. The membrane was assembled in a frame and the performance was tested in terms of concentration of oxygen, flow rate of oxygen enriched air, pressure ratio across the membrane and ambient temperature. Furthermore, the oxygen concentration device was constructed using the membrane, a DC fan, vacuum pump and gas buffer. A nonrandomized preliminary field test was conducted, in which eight healthy male subjects were flown to Tibet (Lhasa, 3,700 m). First, subjects wore the oxygen enrichment device and performed an incremental exercise on cycle ergometer. The test included heart rate (HR), saturation of peripheral oxygen (SpO2) and physical work capacity (PWC). Then, after a rest period of 4 hours, the experimental protocol was repeated without oxygen enrichment device.ResultsThe testing showed that the membrane could increase the oxygen concentration by up to 30%. Simulation test indicated that although the performance of the oxygen enrichment device decreased with altitudes, the oxygen concentration could still maintain 28% with flow rate of enriched air 110 cm3/s at 5000 m. The field test showed that higher SpO2, lower HR, and better PWC (measured by the PWC-170) were observed from all the subjects using oxygen enrichment device compared with non-using (P < 0.01).ConclusionsWe concluded that the new portable oxygen enrichment device would be effective in improving exercise performance when ascending to the high altitude.

Acute high-intensity exercise is a harmful manner associated with a series of myocardial injuries. Metabolism disorder of myocardium is one of the most serious conditions. However, few metabolomics-based studies provide data on the effect of exercise along with myocardial metabolism. Our study aimed to identify metabolic signatures in rat myocardium during acute high-intensity exercise and evaluate their diagnostic potential to sports injuries. SD rats were divided into control group and acute high-intensity exercise group and their myocardium samples were analyzed by LC-MS to explore metabolic alterations of rats’ myocardium. This study showed myocardium metabolism clearly differed between the two groups. there were 6 target metabolic pathways and 12 potential metabolic markers for acute high-intensity exercise. Our findings provide an insight that myocardium metabolism during acute high-intensity exercise have distinct disorders in complex lipids and fatty acids. Moreover, an increase of purine degradation products as well as signs of impaired glucose metabolism were observed. However, the amino acid was enhanced, which had a certain protective effect on the myocardium.

When ascending to the high altitude, people living in low altitude areas will suffer from hypoxia and acute mountain sickness. To reduce the risk of acute mountain sickness, based on the technology of oxygen concentration membrane, we developed a new portable oxygen enrichment device for individual. Eight healthy male subjects were screened and flew to Tibet (Lhasa, 3,700 m) to perform the experiment. First, subjects wore the oxygen enrichment device and performed an incremental exercise on cycle ergometer. The test included heart rate (HR), saturation of peripheral oxygen (SpO 2) and physical work capacity (PWC). Then, after a rest period of 4 hours, the experimental protocol was repeated without oxygen enrichment device. The results showed that higher SpO2, lower HR, and better PWC (measured by the PWC-170) were observed from all the subjects 'with oxygen enrichment device' compared with 'without oxygen enrichment device' (P<0.01). We suggested that the new portable oxygen enrichment device would be effective in improving exercise performance when ascending to the high altitude.

Methods One thousand four hundred and six consecutive patients, who underwent CAG at Daxing hospital from February 2007 through to March 2010 were enrolled. Of the 1406 patients, 351 patients were diagnosed as type 2 diabetes mellitus, 1055 patients were diagnosed as non-diabetic mellitus after admission to hospital. By evaluating the coronary angiogram, the patients were not diagnosed to have coronary heart disease (CHD) with less than 50% diameter stenosis of coronary artery; CHD was defined as narrowing of the appropriate lumen of $50%; the procedure of percutaneous coronary intervention (PCI) were performed in the patients with more than or equal to 70% stenosis; the coronary aortic bypass graft (CABG) surgery had been proposed in patients with left main coronary artery lesions, left main equivalent, diffuse triple coronary artery lesions, two-vessel disease with significant proximal left anterior descending CAD, however the determinations of the therapeutic choice were combined with clinical data. Results The baseline characteristics of patients with and without diabetics undergone coronary angiography were as following. The age was significantly older in patients with diabetes than without diabetes (60.2269.70 vs 57.7669.94, p<0.0005). More femal patients in the diabetes group than non-diabetes group (45.30% vs 35.55%, p<0.0005). The morbidity rate of UAP (64.96% and 49.86%, p<0.0005), and Hypertension (80.06% and 69.57%, p<0.0005) were significantly higher in patients with diabetes than without diabetes. By evaluating the coronary angiogram, more patients were diagnosed to CHD in the diabetes group than in the non-diabetic group (92.59% vs 79.43%, p<0.0005); the proportion of the population of the patients with CHD not indicated for PCI was almost identical in the two groups (23.30% vs 25.97%, p¼0.33); the proportion of the patients with CHD performed the procedure of stent implantation (including the patients receiving follow-up coronary angiography after stenting) were not differ significantly between the two groups (35.61% vs 32.61%, p¼0.30); more patients with CHD were proposed to perform the CABG in the diabetes group than in the non-diabetic group (31.91% vs 17.35%, p<0.0005). Conclusion The morbidity rate of coronary heart disease among patients with type 2 diabetes is greater than non-diabetes, patients with type 2 diabetes have a significantly higher rate of coronary artery bypass grafting which had been proposed. The prognosis of patients with chronic total occlusion (CTO) and diabetes mellitus treated with percutaneous coronary intervention (PCI) is not well known. Methods From Jan 2001 to April 2009, 105 cases of CTO successfully treated with PCI were included. 31 patients with diabetes and 74 without diabetes were compared for angiographic and clinical outcomes (mean follow up 36621 month). Death, myocardial infarction and repeat PCI or coronary artery bypass surgery were considered as a combined primary endpoint. Results 25 diabetes patients (78%) and 67 non-diabetic patients (89%) were trea...