Highlights
There are estimated 1.93 million new CRC cases diagnosed, and 0.94 million CRC caused deaths in 2020 worldwide.
The global new CRC cases is predicted to reach 3.2 million in 2040.
China and the United States have the highest estimated number of new CRC cases in the next 20 years.
The number of new CRC cases is increased from 0.56 million (2020) to 0.91 million (2040) in China.
The number of new CRC cases is increased from 0.16 million (2020) to 0.21 million (2040) in the United States.
The incidence of obesity and colorectal cancer (CRC) has risen rapidly in recent decades. More than 650 million obese and 2 billion overweight individuals are currently living in the world. CRC is the third most common cancer. Obesity is regarded as one of the key environmental risk factors for the pathogenesis of CRC. In the present review, we mainly focus on the epidemiology of obesity and CRC in the world, the United States, and China. We also summarize the molecular mechanisms linking obesity to CRC in different aspects, including nutriology, adipokines and hormones, inflammation, gut microbiota, and bile acids. The unmet medical needs for obesity-related CRC are still remarkable. Understanding the molecular basis of these associations will help develop novel therapeutic targets and approaches for the treatment of obesity-related CRC.
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