IntroductionThe study was designed to explore the possible adverse effects of prenatal polycyclic aromatic hydrocarbons (PAHs) on the neurodevelopment of the infants at the age of 12 months in a birth cohort in Qingdao of China. Benzo[a]pyrene (BaP)-DNA adduct level in umbilical cord blood was measured by enzyme immunoassay.MethodsChild neurodevelopment was assessed at both 6 months and 12 months of age using the Gesell Development Inventory (GDI).ResultsThis study results reveal that multivariate linear analysis, cord BaP-DNA adduct level was inversely associated with developmental quotient score in the adaptive domain [β = −0.08; 95% CI: (−0.16, −0.003); p = 0.04], gross motor domain [β = −0.10; 95% CI: (−0.20, −0.01); p = 0.02], fine motor domain [β = −0.15; 95% CI: (−0.25, −0.05); p = 0.01], language domain [β = −0.12; 95% CI: (−0.21, −0.03); p = 0.02], and personal–social domain [β = −0.13; 95% CI: (−0.22, −0.04); p<0.01]. Further, multivariate logistic regression analysis showed increased cord BaP-DNA adduct levels associated with increased odds of delayed in language domain.ConclusionIn conclusion, the study suggested that prenatal PAH exposure monitored by umbilical cord blood BaP-DNA adducts may adversely affect the neurodevelopment of the infants at 12 months of age.

Objectives: Analysis of the risk factors related to ectopic pregnancy (EP) among intrauterine device (IUD) users in order to reduce the risk of EP from IUD users and to safeguard women's health. Methods: A total of 29 EP cases were collected and 1:1 matched controls in IUD users by case-control study. Results: The data showed that pregnancies had significant association with EP, two pregnancies and three or more pregnancies were increased the risk of EP, adjusted odds ratio AOR = 14.39, 95% CI: 2.37, 87.49 and AOR = 14.87, 95% CI: 2.27, 97.38 respectively. The risk of EP in women of previous abdominal or pelvic surgery was also significantly increased (AOR = 4.43, 95% CI: 1.04, 18.92). While no significant association have been seen with age, first or second time use IUD, periods of insertion, types of IUD, and copper surface area of IUD. Conclusion:The results suggest that the number of pregnancies significantly increase the risk of EP, there is no significant association between the risk of EP and copper surface area or shape of IUD used. Therefore, a woman's individual risk factors will lead to a rise in the risk of EP, there is a need to the suitability of her contraceptive. It is beneficial to reduce the risk of EP by the prevention of unwilling pregnancy and induced abortion.

No abstract