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Review question / Objective: General anesthesia is required during the operation, and different anesthesia drugs and anesthesia methods have different degrees of influence on the central nervous system of patients. Both sevoflurane and propofol can affect neurological function. Some studies have found that inhalation anesthesia of sevoflurane has less effect on postoperative neurological function of INPLASY 1 International Platform of Registered Systematic Review and Meta-analysis Protocols INPLASY PROTOCOL Effects of sevoflurane inhalation anesthesia versus propofoen intravenous anesthesia on postoperative cognitive function in patients with malignant tumors：Meta-analysis Zhang, MX 1 ; Quan, YH 2 . To cite: Zhang et al. Effects of sevoflurane inhalation anesthesia versus propofoen intravenous anesthesia on postoperative cognitive function in patients with malignant tumors：Metaanalysis. Inplasy protocol 202350107.

For capacitive-isolated gate drivers, the pulse width distortion (PWD) and common mode transient immunity (CMTI) are vital factors to evaluate its performance. In this paper, an envelope detection circuit and a dV/dt noise canceling circuit of capacitive-isolated gate drivers is designed based on X-FAB 0.35μm CMOS process. With these structures, this gate driver alleviates PWD and improve CMTI. Spectre simulation results show that the gate driver achieves 200kV/μs CMTI with 50ns propagation delay and maximum 7.4ns PWD. Besides, it has better robustness to fabrication process and temperature variation than conventional methods.

This study was to evaluate the feasibility of near infrared (NIR) fluorescent images as a tool for evaluating the perfusion of the gastric tube after esophagectomy. In addition, we investigated the time required to acquire enough signal to confirm the presence of ischemia in gastric tube after injection of indocyanine green (ICG) through peripheral versus and central venous route. 4 porcine underwent esophagogastrostomy and their right gastric arteries were ligated to mimic ischemic condition of gastric tube. ICG (0.6mg/kg) was intravenously injected and the fluorescence signal-to-background ratios (SBR) were measured by using the custom-built intraoperative color and fluorescence imaging system (ICFIS). We evaluated perfusion of gastric tubes by comparing their SBR with esophageal SBR. In ischemic models, SBR of esophagus was higher than that of gastric tube (2.8±0.54 vs. 1.7±0.37, p<0.05). It showed high esophagus-stomach signal to signal ratio. (SSR, 1.8±0.76). We also could observe recovery of blood perfusion in few minutes after releasing the ligation of right gastric artery. In addition, in comparison study according to the injection route of ICG, The time to acquire signal stabilization was faster in central than in peripheral route (119 ± 65.1 seconds in central route vs. 295±130.4 in peripheral route, p<0.05). NIR fluorescent images could provide the real-time information if there was ischemia or not in gastric tube during operation. And, central injection of ICG might give that information faster than peripheral route.View presentation recording on the SPIE Digital Library: http://dx.

Approximately 90% of all cancer deaths arise from the metastatic spread of primary tumours. Recent reports have demonstrated that the Sonic hedgehog (shh) signaling pathway plays an important role in the metastasis of various organs, including the prostate, pancreas, gastrointestinal tract, esophageal and other tumors. Recently, we found that increased shh producing cells correlate with high migration, invasiveness and increased lymphangiogenesis in Non-small-cell lung cancer (NSCLC), but the mechanism is unknown. Furthermore, blockade of shh pathway by target antibodies inhibited shh-induced tumor growth, metastasis and lymphangiogenesis. In this study, we investigated the hypothesis that expression and function of the shh pathway in human Non-small cell lung cancer. We performed immunohistochemistry on lung tumor biopsies showed that expressions of shh, Gli-1, VEGF-D and LYVE-1 were enhanced in lymph node metastasis specimens compared with lymph node negative lung cancer specimens. To investigate the role of shh signaling as it relates to invasive phenotypes and the motility of NSCLC. We found that recombinant human shh (N-shh) enhanced cell motility and invasiveness in gastric cancer cells, whereas no increase was observed in cells that were treated with KAAD-cyclopamine(SMO inhibitor). The overall cell growth was not affected by treatment with N-Shh when cells were treated with the same concentration and for the same length of time, which indicates that the difference in motility was not due to an effect on proliferation. Reverse transcription-PCR analysis was performed to find lymphangiogenesis factor of mRNA levels. The expressions of shh, Gli-1, VEGF-D and LYVE-1 was also enhanced by treatment with N-shh, but not KAAD-cyclopamine. We further analysed the affects of shh signaling in vitro by stimulating a normal human lymphatic endothelial cell line (HMVEC) with N-shh. In vitro lymphangiogenesis assay using the HMVEC cell line. Stimulation with N-shh enhanced tube formation on matrigel. Stimulation with shh significantly increased in vitro lymphangiogenesis, but not KAAD-cyclopamine. To investigate the role and mechanism for shh signaling in regulating the lymphangiogenetic progression of NSCLC. Tumour hypoxia not only induces tumour angiogenesis, but also modulates the expression of several genes that have been implicated in tumour metastasis. We next explored how the shh signaling and resultant expression of LYVE-1 and VEGF-D regulate metastasis. Because expression of LYVE-1 and VEGF-D may lead to overproduction of reactive oxygen species (ROS), we estimated the amounts of ROS, and found that the N-shh in NSCLC showed enhanced ROS production, whereas the KAAD-cyclopamine did not. These results indicate that shh signaling pathway can contribute to ROS gerenates by enhancing the metastatic and lymphangiogenetic potential of tumor cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1480. doi:10.1158/1538-7445.AM2011-1480