HighlightsOvariectomy accelerates doxycycline-induced acute liver injury.The expression levels of IL-6, IL-10, c-fos, cox-2 and HO-1 genes were strongly upregulated in ovx mice.Apocynin, totally improved DOXY-induced liver injury in both sham and ovx mice.NADPH oxidase is responsible for the development of drug-induced acute liver injury
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