Long noncoding RNA (lncRNA) have emerged as crucial regulators for a myriad of biological processes, and perturbations in their cellular expression levels have often been associated with cancer pathogenesis. In this study, we identified AATBC (apoptosis‐associated transcript in bladder cancer, LOC284837) as a novel lncRNA. AATBC was found to be highly expressed in nasopharyngeal carcinoma (NPC), and increased AATBC expression was associated with poor survival in patients with NPC. Furthermore, AATBC promoted migration and invasion of NPC cells in vitro, as well as metastasis in vivo. AATBC upregulated the expression of the desmosome‐associated protein pinin (PNN) through miR‐1237‐3p sponging. In turn, PNN interacted with the epithelial–mesenchymal transition (EMT) activator ZEB1 and upregulated ZEB1 expression to promote EMT in NPC cells. Collectively, our results indicate that AATBC promotes NPC progression through the miR‐1237‐3p–PNN–ZEB1 axis. Our findings indicate AATBC as a potential prognostic biomarker or therapeutic target in NPC.
Single antenna co-channel interference (CCI) cancellation is a challenge in mobile communication systems, especially for downlink systems. A novel single antenna CCI cancellation algorithm based on lattice reduction (LR) and decision feedback equalization scheme is proposed in this paper. The idea behind the proposed algorithm is to form a multichannel multiuser detection model through over-sampling and then adopts a decision feedback detection method based on LR. Complexity analysis results show that the complexity of the proposed algorithm is quadratic with the memory length of the channels and is nearly independent of the modulation order. Furthermore, simulation results are also presented to indicate the bit error rate performance of the proposed algorithm and its robustness with respect to channel estimation errors.
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