Over half of our HD patients had sufficient RRF. RRF itself may have a beneficial effect on nutritional parameters, and it is important to determine RRF over time, even in chronic HD patients.
Our results indicate that integrin-mediated cell adhesion to the ECM can induce MCP-1 expression through activation of FAK, and suggest a role for altered ECM deposition in the progression of glomerular diseases by affecting gene expression.
Large interindividual variability in peritoneal solute transfer, determined by the peritoneal equilibration test (PET) at the start of peritoneal dialysis (PD) therapy, has been previously shown (1,2). The contributing factors are not well defined, but may include differences in age, peritoneal surface area, peritoneal permeability, or peritoneal blood flow. The structural or functional changes in peritoneal vasculature produced by systemic atherosclerosis may influence peritoneal solute transport properties. In this study, we quantified the degree of systemic atherosclerosis and investigated its correlation with solute transport in the early phase of PD therapy.
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