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Smart phase transformation systems@hard capsule (SPTS@hard capsule) based on lyotropic liquid crystalline (LLC) were developed for oral sustained release in this study. Doxycycline hydrochloride (DOXY) and meloxicam (MLX) were used as hydrophilic and hydrophobic model drug, respectively. Two systems were added with different additives, that is, gelucire 39/01, PEG 1000 and Tween 80 to adjust their melting point and release profiles. The phase transformation of these systems could be triggered by water as well as temperature. They could spontaneously transform into cubic phase or hexagonal phase when coming across with water, to achieve the 24 h sustained release profile. In addition, the obtained systems could switch between semisolid state and liquid state when temperature changed within room temperature and body temperature, which facilitated the phase transformation in gastrointestinal tract and during their encapsulation into hard capsules. LLC-based SPTS@hard capsule revealed potential for the industrialization of its oral administration on account of its drugs accommodation with different solubility, controllable release profile and simple preparation process.

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The art of music, which is a necessary component of daily life and an ideology older than language, reflects the emotions of human reality. Many new elements have been introduced into music as a result of the quick development of technology, gradually altering how people create, perform, and enjoy music. It is incredible to see how actively AI has been used in music applications and music education over the past few years and how significantly it has advanced. AI technology can efficiently pull in the course, stratify complex large-scale music or sections, simplify teaching, improve student understanding of music, solve challenging student problems in class, and simplify the tasks of teachers. The traditional music education model has been modified, and the music education model’s audacious innovation has been made possible by reducing the distance between the teacher and the student. A classification algorithm based on spectrogram and NNS is proposed in light of the advantages in image processing. The abstract features on the spectrogram are automatically extracted using the NNS, which completes the end-to-end learning and avoids the tediousness and inaccuracy of manual feature extraction. This study, which uses experimental analysis to support its findings, demonstrates that different music teaching genres can be accurately classified at a rate of over 90%, which has a positive impact on recognition.

With the emerging of touch-less human-computer interaction techniques and gadgets, mid-air hand gestures have been widely used for authentication. Much literature examined either the usability or security of a handful of gestures. This paper aims at quantifying usability and security of gestures as well as understanding their relationship across multiple gestures. To study gesture-based authentication, we design an authentication method that combines Dynamic Time Warping (DTW) and Support Vector Machine (SVM), and conducted a user study with 42 participants over a period of 6 weeks. We objectively quantify the usability of a gesture by the number of corners and the frame length of all gesture samples, quantify the security using the equal error rate (EER), and the consistency by EER over a period of time. Meanwhile, we obtain subjective evaluation of usability and security by conducting a survey. By examining the responses, we found that the subjective evaluation confirms with the objective ones, and usability is in inverse relationship with security. We studied the consistency of gestures and found that most participants forgot gestures to some degree and reinforcing the memorization of gestures is necessary to improve the authentication performance. Finally, we performed a study with another 17 participants on shoulder surfing attacks, where attackers can observe the victims multiple times. The results show that shoulder surfing does not help to boost the attacks.• We proposed a set of metrics to quantify the usability and security of a gesture, which include objective metrics that are calculated based on gesture samples and subjective