A simple, rapid and efficient system utilizing a coulometric electrode was developed for the preparation of drug metabolites. Trace amounts of reactants are usually generated in electrochemical reactions, which are not suitable for the sufficient preparation of products to obtain NMR and other spectral data for chemical structure confirmation or to obtain data from pharmacological activity screening tests of products. In the developed system, called the "in-flow electrochemical reaction system," a drug, troglitazone, was dissolved in a volatile flow solvent, and pumped into a coulometric electrode under optimized conditions, and the effluent was evaporated. Without any further purification, milligram amounts of a pure oxidation product of troglitazone could be obtained within several hours. The amount obtained was enough for 1 H-and 13 C-NMR analysis by which the structure could be confirmed and was found to be identical to one of the metabolites of troglitazone detected in human plasma. This system will be useful to prepare standard compounds of the required amount for pharmacokinetic study and for toxicokinetic study.

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山口医学 第65巻 第３号 137頁～142頁，2016年 137 腫瘍破裂で出血性ショック状態となった胃GISTの１手術例 平田 健，矢野由香，井口智浩，久我貴之，藤井康宏， 西村純一 １) ，山口裕樹 １) ，三谷伸之 １) ，永富裕二 １) JA山口厚生連 長門総合病院 外科 長門市東深川85(〒759-4194) JA山口厚生連 長門総合病院 内科 １) 長門市東深川85(〒759-4194)

A69-year-oldmanwasadmittedtoourhospitalwithahistoryofupperabdominalpainandanorexia. Upper gastrointestinal endoscopy revealed a tumor in the second portion of the duodenum. Biopsy revealed the diagnosis of undifferentiated pleomorphic sarcoma, and the patient was treated by subtotal stomach-preservingpancreatoduodenectomy.AnabdominalCTperformed2.5monthsafterthesurgery showedalocalrecurrenceandlivermetastases.Treatmentwasstartedwithdoxorubicin,however,the patientdied5.5monthsaftertheoperation.Tothebestofourknowledge,only7casesofduodenalundifferentiated pleomorphic sarcoma have been reported so far, including our case. This case is presented here,alongwithadiscussionoftherelevantliterature.

Using various tea-leaves, fermented tea (Hakkohcha) was newly prepared, which is referred to as "postfermentation tea". As the result of sensory evaluation, no significant di#erence was seen among between likes and dislikes. To examine the protective e#ect of the new fermented tea on carbon tetrachloride (CCl.)-induced acute hepatic injury in rats, the serum GOT and GPT levels were measured and pathological changes were examined. Elevation of GOT and GPT serum levels induced by carbon tetrachloride treatment was significantly suppressed by pre-administration of the new fermented tea. Furthermore, the pathological damage was also reduced. The most e#ective reduction was observed when the tea was orally adminiatered-* min before the CCl.-treatment.