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Greater beta adrenergic receptor density and/or increased myocardial responsiveness to adenylate stimulation in apical myocardium compensates, at least in part, for its sparse sympathetic innervation.

The effects of synthetic rat adrenomedullin (rAM), a novel vasorelaxant peptide originally isolated from human pheochromocytoma. on receptor binding and CAMP generation were studied in cultured rat vascular smooth muscle cells (VSMC). A binding study using ["51]rAM revealed the presence of a single class of high-affinity (& 1.3 x lo-* M) binding sites for rAM m VSMC. The apparent K, of rat calcitonin gene-related peptide (rCGRP) was 3 x lo-' M. Affinity labeling of VSMC membranes with ["'I]rAM revealed two distinct labeled bands with apparent molecular weights of 120 and 70 kDa, both of which were abolished by excess unlabeled rAM or rCGRP. rAM stimulated CAMP formation with an approximate EC,, of lo-* M, the effect of which was additive with isoproterenol, but not with rCGRP. The rAM-induced CAMP response was unaffected by propranalol. indomethacin, or quinacrine, but inhibited by a CGRP receptor antagonist, human CGRP[8-371. These data suggest that VSMC possesses specific AM receptors functionally coupled to adenylate cyclase with which CGRP interacts.

We report preliminary results on the analysis of the three-body Υ( 10860) → B Bπ, Υ(10860) → [B B * + c.c.]π and Υ(10860) → B * B * π decays including an observation of the Υ(10860) → Z ± b (10610)π ∓ → [B B * + c.c.] ± π ∓ and Υ(10860) → Z ± b (10650)π ∓ → [B * B * ] ± π ∓ decays as intermediate channels. We measure branching fractions of the three-body decays to be B(Υ(10860) → [B B * + c.c.] ± π ∓ ) = (28.3 ± 2.9 ± 4.6) × 10 −3 and B(Υ(10860) → [B * B * ] ± π ∓ ) = (14.1 ± 1.9 ± 2.4) × 10 −3 and set 90% C.L. upper limit B(Υ(10860) → [B B] ± π ∓ ) < 4.0 × 10 −3 . We also report results on the amplitude analysis of the three-body Υ(10860) → Υ(nS)π + π − , n = 1, 2, 3 decays and the analysis of the internal structure of the three-body Υ(10860) → h b (mP )π + π − , m = 1, 2 decays. The results are based on a 121.4 fb −1 data sample collected with the Belle detector at a center-of-mass energy near the Υ(10860).

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