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A cervical cancer screening was performed on 204, 186 women in Fukuoka prefecture during 1976-1980 and 167 cases of squamous cell carcinoma, 101 cases of carcinoma in situ (CIS), 4 cases of adenocarcinoma and incidentally

Objective: Cancer treatment for adolescent and young adult (AYA) patients with cancer can have lasting effects on their reproductive health by causing premature menopause. Fertility can be preserved by cryopreservation of oocytes, embryos, or ovarian tissue. Recently, many cases of pregnancy and delivery after ovarian tissue warming and transplantation have been reported. The number of ovarian tissue cryopreservation cases has been increasing in our hospital. Herein, we evaluated the current status of ovarian tissue cryopreservation among AYA patients.Method: Ovarian tissue cryopreservation was performed in nine cases at our hospital between February 2017 and March 2018. In 6 of the 9 patients, oocyte pick-up without controlled ovarian stimulation was performed for both ovaries during the removal of one ovary by laparoscopic surgery. We retrospectively collected data from the patients' medical records. Result:The patients ranged in age from 11 to 43 years, and all the patients were nulligravida. Among these patients, 3 had breast cancer; 2, leukemia; 1, Ewing sarcoma; 1, vulvar sarcoma; 1, mediastinal tumour; and 1, suprasellar germ cell tumour. Five of the 9 patients underwent ovarian tissue cryopreservation after chemotherapy. The mean anti-Müllerian hormone (AMH) level was 1.54 ng/ml. Twenty-six oocytes were collected from 6 patients. Ten oocytes matured in vitro could be cryopreserved. Conclusion:So far, there have been no cases of pregnancy by ovarian tissue warming and transplantation. Further accumulation of cases and consideration is needed to yield any findings on the usefulness of this technique.