Urgency of the research. Taken into consideration the existing advantages of Ukraine as a powerful European State, promising directions of its development is being involved in cross-border cooperation. Target setting. Modern analysis of regional development of Ukraine testifies to the presence of negative trends, in particular, to deepen inter-regional differences, economic disparities and the exacerbation of social problems. Concerning this. crossborder cooperation is becoming an important factor of sustained development of Ukraine, a channel of involvement in European integration. Actual scientific researches and issues analysis. Devoted to problems of euroregìonal policy of Ukraine are the researches of such scholars as V. O. Martynyuk, N. A. Mikula, C. C. Troyan, L. I. Fedulova, T. M. Uhnovska, A. Hubert. Uninvestigated parts of general matters defining. Further analysis is needed for the system of institutional and financial mechanisms of innovative development of euroregions. For Ukraine, urgent is a need of scientific justification of cross-border partnership benefits and problems, as well as a need of developing regulatory procedures providing the clustering process. The research objective. The analysis of the social partnership of Ukraine with the EU in the framework of cross-border clusters and euroregions. The statement of basic materials. The article deals with priorities of cooperation between Ukraine and the EU within the European regions and cross-border clusters. Based on the data SWOT-analysis identified the main objectives of European regions, effective mechanisms for inter-regional cooperation. Conclusions. It is important to implement in national statistical agencies the collection and processing of cross-border statistics in accordance with the recommendations of Eurostat; allocate budget funds for co-financing projects supported by the European Commission; create together with the Governments of neighboring States special funds, which will be accumulating finances to support social initiatives.