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In this paper different methods of processing of speckle pattern are compared. Two configuration of ithimination perfusion by speckle-modulated coherent irradiation and Gaussian beam are analyzed. Optimal optical scheme of digital speckle-mi croscopy is found for monitoring of blood microcirculation.

Different methods of speckle-metrology, which may be used in biomedical diagnostics, are considered in this paper. Cross-correlation technique, digital speckle-photography, LASCA are compared. Advantages and disadvantages of these methods are demonstrated; the limits for minimal resolution are studied.

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