The role of the WTO extenuation in regulation of international trade relations and prolonged stagnation of the world trade market compel individual states to conclude the alternative regional arrangements. Using of various kinds of preferences in the framework of these agreements and elimination of trade barriers is mutually beneficial for all the participants and have a favorable effect on the volumes of foreign trade. Regional trade agreements are an important tool for the development of world economic relations. In conditions of high geopolitical tension, the search for new formats of international cooperation is necessary to increase the competitiveness of the Russian Federation, to increase its share in world commodity markets and to overcome the consequences of imposed sanctions. In this regard, in order to reduce the influence of the political component, it is necessary to activate realization of international and foreign economic relations of the Russian Federation regions. The example is the foreign economic activity of the Lipetsk region, with its active expansion of international ties in terms of exporting products and attracting foreign investments. A great potential for expanding international trade operations has the Asian vector of economic cooperation. The conclusion of new regional trade agreements and further integration expansion of the Asia-Pacific region will attach an impulse to the economy of the Far Eastern regions, ensure the formation of a sustainable multilateral trading system, will create the possibility of using the geographical potential (seaports), and will promote the development of a joint transport and production infrastructure. Keywords-international trade, regional trade agreements, economic cooperation, overcoming of sanctions restrictions, foreign economic relations of the regions of the Russian Federation, international integration.