The purpose of the article is to develop theoretical and methodological proposals and practical recommendations for the formation of a strategy for the optimal transition to a ‘single digital market’ system based on the effective functioning of national innovative infrastructures in the context of expanding digitalization. With the help of SWOT analysis, the structuring of the factors of development of digitalization was carried out. Based on the analysis, a structure for managing the digital economy in Russia was formed. Simulation modelling of optimization of the digital economy in Russia has been carried out. As a result, a strategy was developed for Russia’s transition to a ‘digital single market’. The developed strategy makes it possible to take into account that a quick transition to an efficient digital economy is impossible due to the existing threats to the development of the digital market in Russia. Practical application of the developed strategy for the transition to a ‘digital single market’ will make it possible to more effectively manage emerging threats on the path to digitalization and make optimal use of opportunities for development. At the same time, this strategy is applicable to public sector, business sector and individual households.

This paper draws on the methods of analysis and synthesis to study the regulatory framework governing the modern operating mechanism of the EU single market. Statistical analysis made it possible to reflect the market dynamics with reference to the pre-and post-COVID crisis periods. Consolidation was applied to merge data on the trade of goods and servicesthe key elements of the EU Member States' trade indicators. Finally, the method of comparative analysis was employed to compare the single market environment of the EU with markets of other countries. The functioning of the single market depends on shared responsibility between the EU's centralized management and the many policies of its Member States. There are barriers within the single market system that limit the free movement of goods, services, people and capital and lead to an imbalance. These are sanitary and phytosanitary standards, tariff measures, and technical and quantitative barriers.

<p>Supplementary Figure 8. Heterogeneity in TP53 variant allele frequency in MMRd patients.</p>

<p>Supplementary Figure 7. Immunohistochemical staining of MSH2, MSH6, MLH1, and PMS2.</p>

<p>Supplementary Figure 3. Representative copy number profiles of samples harboring MSH2 and MSH6 deletions.</p>