The root cause of premature culling of animals from the herd as a result of diseases and injuries is a lesion of distal portions of limbs of an infectious etiology, which include Mortellaro's disease. Mortellaro's disease affects up to 60 percent of the cattle in Russia. BelNano was developed, consisting of liposomal fractions and nanoparticles of silver and copper distributed in its volume. The surface of the nanoparticles has been specially modified to provide high efficiency on the skin and keratinized tissues. Pathogens that were found in impression smear and Fusobacterium necrophorum, Treponema, Borellia grown on nutrient media, which were sensitive to the active components of the BelNANO, ensuring their inactivation by action on the cell wall were revealed in the studied animals with Motellaro's disease. In experiments on the study of effectiveness of the BelNANO for the prevention and treatment of skin and skin coverings of the distal portion of limbs in Mortellaro's disease, 89 percent therapeutic efficacy was established, providing not only a high bactericidal and bacteriostatic effect on infectious agents, but also high regenerative properties of the drug, expressed in epithelization and the appearance of granulation tissue. Keywords-skin and skin lesions, Mortellaro's disease, Cu and Ag nanoparticles, lameness, drug for the treatment of interdigital cleft, cattle I.

In the course of research on the search for substances active in the fight against Mortellaro’s disease, a drug for the treatment and prevention of skin and skin diseases was developed and tested on the basis of zinc and copper metals immersed in the niosomal structures with the addition of Dimethicone copolyol. These components were selected as proven antiseptic. The therapeutic effect was compared at different concentrations of metals in the drug. Practical experiments have shown a high therapeutic effectiveness of the received drug for the treatment of skin and skin diseases of animals, including Mortellaro disease.