Rationale:Fluoropyrimidine-induced cardiotoxicity is a rare but potentially serious toxicity. The most common symptom is anginal chest pain.Patient concerns:A 35-year-old woman was diagnosed with rectal cancer with metastasis to the liver.Diagnosis:A computed tomography scan showed a 9.3 × 4.5-cm predominantly hypodense lesion within the left lobe of the liver and thickening of the rectum. Liver biopsy showed moderately differentiated adenocarcinoma with necrosis involving the liver parenchyma, and immunohistochemistry for mismatch repair proteins indicated that the tumor was positive for MutL Homolog 1, MutS Homolog 2, MutS Homolog 6, and Protein Homolog 2. Rectal biopsy indicated moderately differentiated adenocarcinoma.Interventions:She received chemotherapy of fluorouracil 1600 mg/m2, leucovorin 500 mg/m2, and irinotecan 100 mg/m2 every week. During the second cycle of chemotherapy, she developed severe anginal chest pain. We replaced fluorouracil with capecitabine 1500 mg (3 pills) a day every 2 weeks, with 1 week off, with irinotecan 100 mg/m2 on day 1 and bevacizumab 5 mg/kg at 200 ml/h for 30 min every 2 weeks. She was treated with chemotherapy for approximately 6 months.Outcomes:The liver lesion showed a significant response to chemotherapy, so she underwent resection of the liver tumor and rectum. After the surgery, she received radiation therapy to the rectal area, and 3 months of chemotherapy were administered prior to colostomy reversal.Lessons:Although the mechanism of fluoropyrimidine-induced cardiotoxicity is still uncertain, our case provides clinical evidence that cardiotoxicity could be a dose-related complication. Reducing the dose of fluoropyrimidine should be considered as a strategy after fluoropyrimidine-induced cardiotoxicity. However, this must be discussed with a multidisciplinary team including oncologists and cardiologists. Close monitoring of serial biomarkers and echocardiography are necessary for early diagnosis of cardiotoxicity.

Based on the "9+2" city cluster consisting of "nine cities" and "two regions" in the Guangdong-Hong Kong-Macao Greater Bay Area, this paper explores the propagation, heritage and cultural identity of Cantonese opera. On the basis of this study, we explore the willingness of Cantonese opera to spread, the current situation of intergenerational and school heritage, and the role of cultural ties in the Bay Area era, and offer suggestions for the synergy of Cantonese opera and the times. In order to investigate the current situation and effects of Cantonese opera dissemination and the willingness to transmit Cantonese opera, we use the method of constructing logistic regression models; based on the above analysis, we propose suggestions for the future development of Cantonese opera a.

In recent years, the "school district housing boom" has become a general concern as it disrupted the housing market, undermining educational equity and class mobility. In view of the real problem of housing premium in school districts, this paper selects the housing data of primary school districts in Guangzhou as a research sample, quantifies it and discusses the impact of education supply on it, so as to provide references and suggestions for subsequent policy introduction. The main research conclusions of this paper are as follows: There is a premium for housing in Guangzhou’s school districts. After excluding the influence of location and physical factors, it is calculated that the housing price from Longdong School District to Yongping School District has increased by about 42.3%.

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