Purpose:To evaluate the value of diffusion-weighted imaging (DWI) in distinguishing between benign and malignant breast lesions. Materials and Methods:Fifty-two female subjects (mean age ϭ 58 years, age range ϭ 25-75 years) with histopathologically proven breast lesions underwent DWI of the breasts with a single-shot echo-planar imaging (EPI) sequence using large b values. The computed mean apparent diffusion coefficients (ADCs) of the breast lesions and cell density were then correlated. Results:The ADCs varied substantially between benign breast lesions ((1.57 Ϯ 0.23) ϫ 10 -3 mm 2 /second) and malignant breast lesions ((0.97 Ϯ 0.20) ϫ 10 -3 mm 2 /second). In addition, the mean ADCs of the breast lesions correlated well with tumor cellularity (P Ͻ 0.01, r ϭ -0.542). Conclusion:The ADC would be an effective parameter in distinguishing between malignant and benign breast lesions. Further, tumor cellularity has a significant influence on the ADCs obtained in both benign and malignant breast tumors.

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Our study revealed that the consideration of CRC stages would be necessary in diagnostic biomarker discovery, as well as that attention should be paid to the facile loss of methyl chloride from the [M + Cl](-) form of LPC(16:0) in its tandem mass spectrum.

BACKGROUND AND PURPOSE: T2 and ADC mappings are 2 quantitative MR imaging tools for assessing IVDD. This study aimed to compare these 2 measures in detecting IVDD and its age-related changes.