The research aimed to recognize the EFT effect on the stress reduction of diabetes mellitus patients.  The Research used a quasi-experimental design non-randomization pre-test – post-test group design. The ‘t’ value for stress level before EFT was performed with a p-value of 0,000 and for stress level after EFT p-value was 0,000. From the statistic, it was concluded that there was a significant EFT effect on stress reduction in patients with diabetes mellitus. The Emotional Freedom Technique (EFT) including the mind-body therapy relaxation technique was an integrated system between energy medicine and EFT therapy using a tapping method on body meridian points.  EFT therapy firmly helped the patients to manage their minds from emotional pressure (negative energy) therefore it helped patients with stress. It helped all patients mainly patients with diabetes mellitus.