No abstract

Florfenicol (FF) is a novel animal-specific amidohydrin broad-spectrum antibiotic. However, its aqueous solubility is extremely poor, far below the effective dose required for veterinary clinic. Thus, FF is often used in large doses, which significantly limits its preparation and application. To overcome these shortcomings, the FF-hydroxypropyl-β-cyclodextrin (FF-HP-β-CD) inclusion complexes were developed using the solution-stirring method. The physical properties of FF-HP-β-CD were characterized. A comparison was conducted between FF and FF-HP-β-CD freeze-dried powder injection of their muscle irritation and the pharmacokinetics. The drug loading and saturated solubility of FF-HP-β-CD at 37 °C were 11.78% ± 0.04% and 78.93 ± 0.42 mg/mL, respectively (35.4-fold compared with FF). Results of scanning electron microscopy, differential scanning calorimetry, X-ray diffraction, and Fourier transform infrared showed that FF was entrapped in the inner cavity of HP-β-CD, and the inclusion complex formed in an amorphous state. In comparison with FF commercial injection, FF-HP-β-CD increased the elimination half-life (t1/2β), transport rate constant (K10, K12, K21), and maximum concentration (Cmax) after intramuscular injection in beagle dogs. Conversely, it decreased the distribution half-life (t1/2α), absorption rate constant (Ka), apparent volume of distribution (V1/F), and peak time (Tmax). These results suggest that FF-HP-β-CD freeze-dried powder injection is a promising formulation for clinical application.

The elimination of poverty and hunger in all its forms and dimensions is one of the key objective of global sustainable development (GSD). This paper analyzed the characteristics of literature release, research progress and frontier trends in the field of anti-poverty in the past ten years by means of bibliometrics, and information visualization. Using CiteSpace to analyze the literature on anti-poverty in the core journals of Web of Science and Scopus (W&S), and China National Knowledge Infrastructure (CNKI). The results showed that:(1) The heat of anti-poverty research is on the rise in both W&S and CNKI, the growth rate of Chinese literature published is significantly higher than that of English literature after 2015, but the international influence is not enough. (2) Researchers and institutions in W&S are more independent than in CNKI. The Chinese research team is more stable and larger, but it needs to be further strengthened in cross-institutional and interdisciplinary research. (3)The research content in W&S mainly focuses on influencing factors and poverty reduction mechanisms, ecosystem services, maternal health and sustainable development. According to the China National Knowledge Infrastructure (CNKI), China paid more attention to concrete ways to reduce poverty, and after completing the fight against absolute poverty by 2020, China will pay more attention to reducing relative poverty and solve multi-dimensional poverty problems by improving the security of medical care, education and housing conditions.

Farmers’ cooperatives play an important role in enabling small farmers to integrate into modern agriculture. Based on the survey data of 7200 farmers in four provinces of China, this paper uses the multi-dimensional poverty measurement method and the instrumental variable method to reveal the transmission mechanism and multi-dimensional poverty reduction effect of farmers’ cooperatives in deep poverty-stricken areas in China to realize joint agricultural empowerment through the supply chain. The results show that farmers’ cooperatives play an important role in enhancing small farmers’ financing, technology application, market sales, and rights decision-making. Every increase in the degree of interest connection between the two will help farmers reduce the multi-dimensional poverty level by 12.3%, and the mitigation effects on material poverty, ability poverty, and rights poverty are between 10% and 13%. Compared with agricultural cooperatives with weak organizational service capacity, cooperatives with high organizational service capacity have a more significant multi-dimensional poverty reduction effect on farmers, which leads to farmers obtaining financing and improving their ability and income. In addition, the difference in benefit coupling between agricultural cooperatives and farmers of different leading bodies also results in the heterogeneity of multi-dimensional poverty alleviation effects of farmers. To a certain extent, the supply chain is affected by the risk endowment of members, the supply chain’s poverty alleviation performance is affected by members’ supply chain’s poverty alleviation performance, and there is a certain risk transfer and “distribution failure”. Therefore, optimizing the benefit coupling structure and risk sharing mechanism between farmers’ cooperatives and farmers has become an important way to break the pattern of “the strong are always strong” and “distribution failure” for supply chain members and farmers.