The first facile and efficient palladium-catalyzed selective hydroamination of aliphatic alkenes with hydrazides as nitrogen-based reaction partners has been described. This method provides a divergent and regioselective access to a variety of γand δ-hydrazide substituted amide derivatives.The 8-aminoquinolyl directing group could be readily removed to afford the corresponding γand δ-hydrazide substituted carboxylic acid derivatives that are commonly seen in drug molecules and other bioactive compounds.