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Background: Adherence to lymphatic filariasis (LF) medication during the mass drug administration (MDA) program is an important factor for the success of the LF elimination program. Low adherence rate will likely increase the risk of filariasis transmission in the community. This study was aimed to explore factors associated with medication adherence among populations inSubang, West Java, Indonesia. Method: The researchers analyzed a subset of data obtained from 2017 LF multicenter study in Subang. 676 respondents were included in the analysis. Sociodemographic data including age, sex, marital status, and occupation as well as knowledge, attitude, and practices (KAPs) were collected. Multivariate analysis was performed to examine the effect of sociodemographic and KAPs on the adherence to anti-filariasis treatment. Results: In bivariate analysis, adherence was associated with attitude, gender, age, education and knowledge. In the multivariable model, adherence was significantly associated with education and knowledge. Conclusion: factors of education and knowledge were associated with medication adherence among populations in Subang. Socialization/monitoring of certain groups needs to be intensified to improve compliance and coverage of MDA so that the target of LF elimination can be achieved.

The filariasis mass drug administration (MDA) program is one of the strategies to eliminate lymphatic filariasis. First round coverage in Kuningan Regency was 85.4%, but only 50% of sub-districts have reached the target. The aim of this research was to determine the improvement of knowledge, attitude, and practice (KAP) of health cadres through intervention to increase the filariasis MDA coverage in Kuningan Regency. A quasi-experimental research was conducted in Cibeureum and Cibingbin Sub-District of Kuningan Regency using pretest-posttest design from May to October 2016. Selected subjects of this research were 32 health cadres who were given intervention in the form of workshop utilizing leaflets, handbooks, and video. The difference is treatment group was taught about filariasis related materials by an expert but the control group was not. Data were analyzed with paired t-test. The result showed that there was a significant difference between pre-test and post-test in terms of KAP in both groups with p-value of 0,000, but there was no difference in value between the two groups. Thus, the study concluded that training on cadres with a filariasis expert could be an effective strategy as to increase MDA coverage.

ABSTRAKUpaya pengendalian Demam Berdarah Dengue (DBD) secara kimiawi dapat berbahaya bagi manusia dan lingkungannya, sehingga perlu insektisida hayati yang berasal dari tumbuhan seperti Pongamia pinnata. Penelitian ini bertujuan untuk mengetahui aktivitas larvasida berbagai ekstrak biji P. pinnata terhadap kematian larva Aedes spp. Jenis penelitian adalah eksperimen dengan post test only with control group design. Bahan yang digunakan yaitu ekstrak biji P. pinnata dengan pelarut air, metanol dan kloroform. Ekstrak biji P. pinnata diuji terhadap larva instar III Ae. aegypti dan Ae. albopictus dengan konsentrasi masing-masing kelompok 100 ppm, 200 ppm, 300 ppm, 400 ppm dan 500 ppm, kemudian diamati selama 24 jam. Masing-masing uji dilakukan dengan 3 kali pengulangan pada hari yang sama. Hasil penelitian menunjukkan bahwa kematian larva hanya ditemukan pada ekstrak biji P. pinnata dengan pelarut metanol dan kloroform. Nilai LC50 ekstrak P. pinnata dengan pelarut metanol adalah 141,88 ppm terhadap Ae. aegypti dan 108,19 ppm terhadap Ae. albopictus. Sedangkan nilai LC50 ekstrak P. pinnata dengan pelarut kloroform adalah 346,06 ppm terhadap Ae. aegypti dan 222,29 ppm terhadap Ae. albopictus. Hasil tersebut membuktikan bahwa ekstrak biji P. pinnata dengan pelarut air tidak efektif sebagai larvasida, sedangkan ekstrak dengan pelarut metanol dan kloroform mempunyai potensi sebagai larvasida. ABSTRACTThe use of chemical compound as a way to control DHF may cause harmful effect for humans and environment. It is necessary to develop biological insecticides derived from plants such as Pongamia pinnata. This study was designed to determine the larvicidal activity of P. pinnata seeds extract with various solvent on Aedes spp. This study was an experimental research with post test only control group design. Materials used in the research were P. pinnata seed extracts with water, methanol and chloroform solvents of concentration; 100 ppm, 200 ppm, 300 ppm, 400 ppm and 500 ppm. Larvicidal activity of P. pinnata seed extracts was tested against third instar larvae of Ae. aegypti and Ae. albopictus, 24 hours observation was carried out within each treatment. Every test was repeated for 3 times. The result showed that larvae mortality was found in the methanol extract with LC50 value of 141.88 ppm for Ae. aegypti and 108.19 for Ae. albopictus, and in the chloroform extract with LC50 value of 346.06 ppm for Ae. aegypti and 222.29 ppm for Ae. albopictus. The water extract of P. pinnata seed was not effective as a larvicidal, while methanol and chloroform of P. pinnata seed extracts act as potential natural insecticide.

Pekalongan district has completed mass drug administration (MDA) of lymphatic filariasis (LF) for two rounds but still remains positive for microfilariae (Mf rate) > 1%. This study aimed was to assess the prevalence of Wuchereria bancrofti and its association with sociodemographic among the adult community to the incidence of lymphatic filariasis. This study is an analytic study with a cross-sectional design. The prevalence of W. bancrofti was detected by the presence of circulating filarial antigen (CFA) using a filarial test strip (FTS). The study population consisted of an adult group living in ten villages in the Pekalongan district's low-endemic region, with 1804 samples collected from 72 clusters. Statistical analysis was performed to test the difference between variables. There were 13 (0.72%) positive W. bancrofti antigen samples out of 1804 total samples. Males were found to be infected at a higher rate than females (61.5%). The age of subjects infected with W. bancrofti was dominated in the range of 13-50 years as many as 9 people (69.2%). The proportion of positive CFA in Medono village with the highest proportion was 6 people (2.7%). There was no statistically significant difference between gender and age with LF cases, but it is significantly different by sub-district (p-value = 0.041). LF transmission occurred in border areas between high and low endemic LF areas. MDA implementation must be constantly supervised in required to address the elimination target.