Solid state physics is the basis of quantum mechanics to study the microstructure and macro properties of crystal materials. The combination of the two can promote the further improvement and development of the structure and properties of solid materials. Under the background of computer application, the development of quantum mechanics is inseparable from the effective support of solid-state physics. It can be seen that the relationship between solid-state physics and quantum mechanics is mutual promotion and correlation. Based on this, this paper first studies the key points of quantum mechanics and its relationship with solid state physics, and then analyses the concrete relationship between quantum mechanics and solid state physics based on computer.