Objectives: To evaluate the incidence and mortality of acute respiratory distress syndrome (ARDS) in medical/ respiratory intensive care units (MICUs/RICUs) to assess ventilation management and the use of adjunct therapy in routine clinical practice for patients fulfilling the Berlin definition of ARDS in mainland China. Methods: This was a multicentre prospective longitudinal study. Patients who met the Berlin definition of ARDS were included. Baseline data and data on ventilator management and the use of adjunct therapy were collected. Results: Of the 18,793 patients admitted to participating ICUs during the study timeframe, 672 patients fulfilled the Berlin ARDS criteria and 527 patients were included in the analysis. The most common predisposing factor for ARDS in 402 (77.0) patients was pneumonia. The prevalence rates were 9.7% (51/527) for mild ARDS, 47.4% (250/527) for moderate ARDS, and 42.9% (226/527) for severe ARDS. In total, 400 (75.9%) patients were managed with invasive mechanical ventilation during their ICU stays. All ARDS patients received a tidal volume of 6.8 (5.8-7.9) mL/kg of their predicted body weight and a positive end-expository pressure (PEEP) of 8 (6-12) cmH 2 O. Recruitment manoeuvres (RMs) and prone positioning were used in 61 (15.3%) and 85 (16.1%) ventilated patients, respectively. Life-sustaining care was withdrawn from 92 (17.5%) patients. When these patients were included in the mortality analysis, 244 (46.3%) ARDS patients (16 (31.4%) with mild ARDS, 101 (40.4%) with moderate ARDS, and 127 (56.2%) with severe ARDS) died in the hospital.

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In this paper, we demonstrate three key features of oxide-based nano-oscillators: 1) the observation of threshold switching and filamentary oscillations in TaO x ; 2) the highest frequency achieved by oxide-based oscillators; and 3) a study with linear (resistor) and nonlinear (transistor) ballasts to clearly understand the role of filament dynamics in scaling. These oscillators show frequency tunability over the range of 20 kHz-250 MHz, with 250 MHz being the highest reported frequency for this class of oscillators. Different types of ballasts show frequency tunability using two distinct methods: 1) by tuning the channel resistance of the transistor and 2) by increasing the rail voltage across the ballast-device pair. This sheds new light on the oscillator dynamics for dense oscillator arrays aimed at oscillatory neural networks and other applications.Index Terms-One transistor, one resistor (1T1R), compact oscillator, filament dynamics, filament formation, forming, high frequency, metal-insulator transition, oscillatory neural network (ONN), oxide oscillators, resistive random access memory (RRAM), TaO x .

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