In prenatal diagnosis, chromosomal aberrations, such as aneuploidies and copy number variation (CNV), are one of the important reasons for ultrasound structural abnormalities and products of conceptions (POC). CNVs are pervasive in human genome and account for a large fraction of the population diversity in humans (Girirajan, Campbell, & Eichler, 2011). Many CNVs located in specific genome regions also have clinical significance or have strong associations with well-characterized genomic disorders, such as 22q11 deletion syndrome (Velocardiofacial/DiGeorge syndrome; Faas et al.,