No abstract

A mild and efficient DBN-mediated addition reaction of α-(trifluoromethyl)styrenes with diazoles, triazoles, tetrazoles, and primary, secondary, and secondary cyclic amines was developed. This practical protocol provided a robust method for the synthesis of various βtrifluoromethyl nitrogen-containing heterocycles and β-trifluoromethyl amines.

A facile and practical method for the synthesis of 2,3,4-trisubstituted 2-aminothiophenes by the cyclization of gem-dibromoalkenes or gem-dichloroalkenes with β-keto tertiary thioamides has been developed.

An efficient solvent-free synthesis of β-CF3-substituted phosphonates and phosphine oxides via hydrophosphonylation and hydrophosphinylation of α-CF3 styrenes with H-phosphonates and H-phosphine oxides was developed.

A highly efficient solvent-controlled synthesis of bis(trifluoromethyl)cyclopropanes and bis(trifluoromethyl)pyrazolines via a [2 + 1] or [3 + 2] cycloaddition reaction of 2-trifluoromethyl-1,3-conjugated enynes with CF3CHN2 was developed.