The textbook contains information on new technologies of radiation diagnostics and therapy of oncological diseases, new and promising therapeutic and diagnostic radiopharmaceuticals, new directions in nuclear medicine in Russia and in developed foreign countries, as well as on the coordination of efforts of international organizations to maintain and improve the health of the population of different countries. The active activity of the Rosatom State Corporation on the introduction and development of programs for the non-energy use of nuclear and radiation technologies to improve the health of the world's population, as well as training and training programs for high-tech medicine, combating widespread epidemic diseases, improving health systems in Russia and developing countries is shown. The basic nuclear-physical and therapeutic-diagnostic requirements for radionuclides and radiopharmaceutical drugs used in nuclear medicine are described. Information on the clinical application of new therapeutic and diagnostic tools developed in Russia for the needs of nuclear medicine is presented. In a comparative aspect, a brief description of educational programs of academic training of specialists for high-tech medicine in Russia and developed countries is given. Meets the requirements of the federal state educational standards of higher education of the latest generation 03.04.02 "Physics" (profile "Medical physics", educational programs "Medical physics of nuclear medicine" and "Medical physics of radiation diagnostics and therapy") and 30.05.02 "Medical biophysics". It is intended for students of master's programs and postgraduates of various specialties — biomedical, physico-chemical, biological, environmental, pharmaceutical. It can be useful for university teachers, as well as for specialists in the application of nuclear and radiation technologies, developers of new methods, systems and technologies for the diagnosis and treatment of diseases in humans.