Coronavirus has the greatest effect on the human lungs. This is why lungs of patients with COVID- 19 require constant medical monitoring. One of the tools for the lungs condition monitoring is based on the wireless pulse oximeters connected to smartphones. There is an attempt to analyze the types of pulse oximeters, their technical characteristics, principles of operation and basic requirements for these measuring instruments in the article. According to this study, the most effective pulse oximeters for 24/7 monitoring of lung function were selected. Principles of pulse oximeter functioning and mathematical basis of its operation have been described. The criteria for pulse oximeter selection have been determined, and comparative analysis of pulse oximeters with wireless communication has been conducted.

The article presents the development of conceptual models of buildings constructed with using Building Information Modeling software complexes. It describes the advantages and disadvantages of modern additive technologies. Features of their using are specified. Examples of their integration in modern construction are shown. Construction areas for which building models were developed were selected. The main ways of development of construction in the selected areas of activity are indicated. An analysis of current trends in the field of architecture is presented, and a forecast of future architectural trends for the coming decades based on the results provided by 3D Fast Build technology is made. The functional features of the buildings construction of the designated time period are taken into account. They were theoretically integrated into selected objects related to various construction areas, with their further design and modeling in the Autodesk Revit program, taking into account all identified trends and expected functionality.

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The purpose was to determine content of the main active components — macro- and microelements — in thermal water, in the intermediate product (concentrate) and in the dosage form (spray). Determining the saturation of the dosage form with active components was the purpose as well. Materials and methods. Thermal water from the Nizhne-Paratunskiye springs of Kamchatka, concentrate from this water, composition with a concentrate of thermal water in the form of spray were used. Determination of the content of calcium and magnesium ions was carried out by titrimetric method on the basis of forming a complex compound with Trilon B. Validation of the used methods was carried out. Its repeatability was evaluated within one day to determine the precision of the technique. The intra- and inter-assay precision of the validated method was also evaluated. Solutions containing calcium and magnesium ions in concentrations of 80–120 % from the declared amount were prepared to determine linearity of the methods. Results. The content of magnesium and calcium ions in the raw material (3.63 and 284.41 mg/l, respectively), the intermediate product — concentrate (35.38 and 2723.00 mg/l) and the finished form — spray (11 and 778 mg/l) was determined. Conclusion. As a result of studies based on the determination of the content of macro- and microelements in the spray, concentrate, dosage form, it was found that it is possible to achieve an increase in the content of the trace elements in thermal water, thanks to its 10-fold concentration, which will reduce the cost of transportation. Using the concentrate it is possible to achieve the required salt concentration in the finished product. The developed spray has a complex of auxiliary substances that provide the required consistency of the composition, easily releases hydrothermal water, is chemically indifferent, compatible with salts, absorbs liquid well, is easily removed from the application site, leaves no traces.