Objective: To determine the perception of medical students about factors affecting academic performance and to associate them with academic performance. Study Design: Cross sectional.Place and Duration of Study: The study was carried out in the Department of Community Medicine at Wah Medical College, Wah Cantt from January 2018 to August 2018.Materials and Methods: After explaining purpose of the study and taking informed consent, questionnaires were distributed to students and collected after two days. Data was analyzed by SPSS version 19. Frequency tables and charts were constructed for qualitative and quantitative variables accordingly.  Association of academic performance with factors affecting academic performance were determined by chi-square.Results: The factors that affect the academic performance most were parental concern (87.2%), time spent on social media (78.4%), influence of friends (74.4%), silence during study (88.8%) and style of teaching (80.8%). Significant association was found between academic performance and place of residence, daily breakfast, peer academic performance, night study and joining medical profession on own will.Conclusion: Supervision by parents, academically competent peers, apposite institutional environment, pertinent use of media and good teaching strategies mostly affect the academic performance.How to cite this: Khan KW, Ramzan M, Zia Y, Zafar Y, Khan M, Saeed H. Factors Affecting Academic Performance of Medical Students. Life and Science. 2020; 1(1): 8-11.  doi: https://doi.org/10.37185/L&S.1.1.45