The stress level of nurses in hospitals can be high. The ability of nurses to identify sources of stress in the workplace is very important. This systematic review aimed to describe the factors that influence the work stress of nurses in hospitals. Studies were obtained from databases including Google Scholar, Garuda portal and PubMed, and were restricted to articles published from 2010-2020. The researchers found 2,119 articles (1,999 articles on Google Scholar, 72 articles on the Garuda Portal, and 48 articles on PubMed). The researchers duplicated the critical appraisal and narrative synthesis of these articles and finally, data were extracted from 78 articles. There were 33 factors identified as causing work stress in nurses. Of these factors, workload, work environment, and work-family conflict were the most influential factors. It is recommended for nurses who serve in hospitals to try to overcome work stress by paying attention to what factors can affect work stress, because this stress can negatively impact their performance and decrease the quality of nursing services in hospitals. Keywords: hospital, nurse, workplace stress