Abstract Women are prone to experiencing postpartum depression. The purpose of this study was to analyze the association of risk factors and depression symptoms in postpartum mothers in Banjarsari District, Surakarta in 2019. The design of the research is cross-sectional with the total sample was.160 postpartum mothers (0-6 weeks) from the total population of 268 mothers The independent variables included the mother’s age, education, occupation, type of delivery exclusive breastfeeding practice, and the first time breastfeeding. Whereas, the dependent variables were the symptoms of postpartum depression. Data collection using the exclusive breastfeeding practice questionnaire and the Edinburgh Postnatal Depression Scale (EPDS). Data analysis was performed using Chi-square and multivariate logistic regression. The results showed that 25.6% of mothers in Banjarsari experienced symptoms of postpartum depression. Type of labor (p=0,049, OR 2,333, 95% CI 1,002-5,428) and exclusive breastfeeding practice (p=0,018, OR 2,460 95% CI 1,1665,187) were significantly associated with symptoms of postpartum depression. The study concluded that the group of mothers who did exclusive breastfeed and who had delivery complications tended to experience symptoms of postpartum depression higher than that of mothers who did not experience the same conditions. Keywords : postpartum, depression, EPDS Abstrak Perempuan rentan mengalami depresi masa nifas. Tujuan penelitian untuk menganalisis hubungan faktor risiko dengan gejala depresi pada ibu di masa nifas di Kecamatan Banjarsari, Surakarta. Desain penelitian adalah crossectional dengan sampel 160 ibu nifas (0-6 minggu) dari total populasi 268 orang, Penelitian mengukur variabel independen yaitu usia ibu, pendidikan, pekerjaan, jenis persalinan, praktik menyusui eksklusif dan waktu pertama kali menyusui dengan variabel dependen yaitu gejala depresi pada ibu di masa nifas. Pengumpulan data menggunakan kuesioner praktik menyusui eksklusif dan Edinburgh Postnatal Depression Scale (EPDS). Analisis data menggunakan Chi-square dan multivariat menggunakan regresi logistik. Hasil penelitian menunjukkan 25,6% ibu di Kecamatan Banjarsari, Surakarta mengalami gejala depresi di masa nifas. Jenis persalinan (p=0,049, OR 2,333, 95% CI 1,002-5,428) dan praktik menyusui eksklusif (p=0,018, OR 2,460, 95% CI 1,166-5,187) berhubungan signifikan dengan gejala depresi masa nifas. Kesimpulan penelitian ini adalah kelompok ibu yang tidak menyusui eksklusif dan kelompok ibu yang jenis persalinan disertai penyulit cenderung mengalami gejala depresi lebih tinggi dibandingkan kelompok ibu yang tidak mengalami kondisi yang sama. Kata kunci: postpartum, depresi, EPDS