This study investigates the curative response of ethanol extract of Cassia sieberiana leaves (EECSL) on testosterone-induced benign prostatic hyperplasia (BPH). Thirty rats of 11-12 weeks old weighing 120-160 g were grouped into six of five rats each. Group 1 was the normal control; groups 2-6 were induced with testosterone (5 mg/kg body weight) for 21 days following standard procedures. Group 2 serves as BPH-control, groups 3 received finasteride while 4-6 received orally 100, 300, and 500 mg/kg of EECSL, respectively for 14 days. Biochemical and BPH indices were analyzed. Oral administration of EECSL showed a decrease in prostate weight, Prostate-specific antigen (PSA), testosterone and dihydrotestosterone (DHT), triacylglycerol (TAG), total cholesterol (TC), lowdensity lipoprotein (LDL), malondialdehyde (MDA), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) whereas an elevation in high-density lipoprotein (HDL), GSH and likewise antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) activities were recorded. The histology photomicrographs showed that EECSL restored lesions of testosterone induction in the treated groups. Our study reveals that EECSL exerts potent on BPH, hypolipidaemic, and antioxidant potentials and justifies the claims by the traditional doctors in BPH management.

Diabetes mellitus (DM) is a chronic disease characterized by a relative or absolute lack of insulin secretion or insulin inaction. The study investigated the effect of Annona cherimola leaf extract on the liver and kidney function indices of alloxan-induced diabetic rats. A total of twenty (20) albino rats of both sexes weighing about 100g to 200g were used for the study, while eighteen (18) mice were used for the acute toxicity study. The animals were randomly divided into five (5) groups of four (4) rats each; Group 1 was not induced nor treated (normal control), group 2 was induced but not treated (untreated control), group 3 was induced and treated with 100 mg/kg b.w. of metformin (standard control), and groups 4 and 5 were induced and treated with 100 and 200 mg/kg b.w. of the extract respectively. The induction of diabetes was achieved by intraperitoneal injection of alloxan monohydrate (150 mg/kg b.w.). The oral administration (treatment) was done once per day using gavages for fifteen (15) days, and the blood glucose level was checked every three (3) days. The result indicated the extract possessed significant (p < 0.05) antidiabetic effect on groups 4 and 5 compared to the untreated group. A significant (p < 0.05) increase in serum total cholesterol (TC) and triglyceride (TAG) was also observed in groups 4 and 5 compared to the untreated group. In conclusion, this research showed that the ethanol leaf extract of Annona cherimolapossess a potent ameliorative effect in alloxan-induced diabetic rats.

This study investigates the curative response of ethanol extract of Cassia sieberiana leaves (EECSL) on testosterone-induced benign prostatic hyperplasia (BPH). Thirty rats (120-160 g) were grouped into six of five rats each. Group 1 was the normal control; groups 2-6 were induced with testosterone (5 mg/kg body weight) for twenty-one days following standard procedures. Group 2 serves as BPH-control, groups 3 received finasteride while 4-6 received orally 100, 300 and 500 mg/kg of EECSL respectively for 14 days. Biochemical and BPH indices were analyzed. Oral administration of EECSL showed a decrease in prostate weight, Prostate specific antigen (PSA), testosterone and dihydrotestosterone (DHT), triacylglycerol (TAG), total cholesterol (TC), low density lipoprotein (LDL), malondialdehyde (MDA), aspartate aminotransferase (AST) alanine aminotransferase (ALT) whereas an elevation in High density lipoprotein (HDL), GSH and likewise antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) activities were recorded. The histology photomicrograph showed that EECSL restored lesions of testosterone induction in the treated groups. Our study reveals that EECSL exert potent on BPH, hypolipidaemic and antioxidant potentials and justifies the claims by the traditional doctors in BPH management.