A highly efficient manganese‐promoted oxidative cyclization of unsaturated oximes to afford the corresponding 4,5‐dihydroisoxazoline alcohols was developed. A very low loading (generally 0.1–0.2 mol‐%) of Mn(acac)3 (acac = acetylacetonate) promoted the oxidative cyclization through the direct incorporation of molecular oxygen present in air (open flask) at room temperature.
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