Studying the urban entrepreneurship environment has guiding significance for the development of urban economy and employment. Based on the PSR (Pressure-State-Response) model framework, this paper constructs an index system for evaluation of urban entrepreneurship environment, and uses the multi-factor weighted method to systematically quantitatively analyze and comprehensively evaluate the state of entrepreneurship policies, service systems, and hardware facilities, and use GM(1, 1) model to predict the development trend of urban entrepreneurship environment in Guangzhou. The study shows that the policy measures to optimize the entrepreneurship environment have effectiveness, time lag and accumulation effect, and the government's response measures are the core factors for the stable development of the urban entrepreneurship environment. It is expected that the entrepreneurship environment in Guangzhou will continue to improve in the future. Finally, it is pointed out that optimizing the urban entrepreneurship environment should start from innovation, attracting talents, increasing financial support, and highlighting regional industrial characteristics to form an entrepreneurship economy.