In this work, we
reported a multi-responsive luminescent hydrogel
with properties of encryption, naked eye sensing of glucose, shape
memory, self-healing, and antibacterial activity. The hydrogel (GA/CCS/DNSA/Eu3+) was obtained by mixing phenylboronic acid-modified gelatin
(GA-DBA), catechol-modified carboxymethyl chitosan (CCS-PCA), 3,5-dinitrosalicylic
acid (DNSA), and Eu3+ ions through a facile heating–cooling
process. The resultant hydrogel exhibits reversible luminescence and
color and phase changes in response to temperature, acid/base, salt,
and redox stimuli. Based on the multiple responsiveness, information
encryption and decryption, naked eye sensing of glucose, remarkable
shape memory, and enhanced mechanical properties of the as-prepared
hydrogel were realized. In addition, the self-healing capacity was
also achieved due to the dynamic bonds in GA/CCS/DNSA/Eu3+ hydrogels. Specifically, the GA/CCS/DNSA/Eu3+ hydrogels
possess antibacterial activity owing to the bacteriostasis of the
CCS-PCA and DNSA/Eu3+ complex. Thus, GA/CCS/DNSA/Eu3+ hydrogels have potential applications in the fields of anticounterfeiting,
wearable devices, biomedicine, sensing, etc.
Purpose To investigate the effect of sevoflurane preconditioning on
ischemia/reperfusion (I/R)-induced pulmonary/hepatic injuryMethods Fifty-one Wistar rats were randomly grouped into sham, I/R, and sevoflurane
groups. After reperfusion, the structural change of the lung was measured by
Smith score, the wet and dry weights (W/D) were determined, malondialdehyde
(MDA) myeloperoxidase (MPO) content was determined colorimetrically and by
fluorescence, respectively, and matrix metalloprotein-9 (MMP-9) mRNA was
quantified by RT-PCR. Biopsy and morphological analyses were performed on
liver tissue, activities of aspartate aminotransferase (AST) and alanine
aminotransferase (ALT) were determined, and tumor necrosis factor-alpha
(TNF-α) level was determined.Results The sham group showed no changes in tissue structure. Structural lesions in
the sevoflurane and I/R groups were mild and severe, respectively. Smith
score, W/D, MDA, MPO, and MMP mRNA showed the same trend, and were increased
in the I/R group and recovered in the sevoflurane group, compared with the
sham group (both P<0.05). AST and ALT were significantly increased
compared to the sham group (AST: 655±52.06 vs . 29±9.30
U/L; ALT: 693±75.56 vs . 37±6.71 U/L; P<0.05). In the
sevoflurane group, AST and ALT levels were significantly decreased
(464±47.71 and 516±78.84 U/L; P<0.001). TNF-α presented similar
results.Conclusion The protection of lung and liver by sevoflurane may be mediated by inhibited
leukocyte recruitment and MMP-9 secretion.
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