Easy access: In the presence of Rh/C in D2O under H2 at 160 °C the H/D exchange reaction of unfunctionalized alkanes can easily occur (see scheme). Inexpensive reagents and mild reaction conditions are used, and fully deuterated products can be obtained after a simple work up procedure.

Abstract:The convenient and regioselective deuteration of hydroxy groups on vicinal carbons was achieved by the combination of 5% ruthenium on carbon (Ru/C), hydrogen gas and deuterium oxide (D 2 O).

Ganz einfach gelingt der H/D‐Austausch nichtfunktionalisierter Alkane in Gegenwart von Rh/C in D2O unter H2 bei 160 °C (siehe Schema). Mit billigen Reagentien und unter milden Reaktionsbedingungen können – nach einer einfachen Aufarbeitung – vollständig deuterierte Produkte erhalten werden.

A hydroxyl group was readily and directly introduced into the a-position of a variety of b-dicarbonyl compounds by heterogeneous Pd/C-catalyzed oxygenation using molecular oxygen.

Hydroxylation O 0216 Pd/C-Catalyzed Direct α-Oxygenation of 1,3-Dicarbonyl Compounds Using Molecular Oxygen. -Introduction of a hydroxyl group in the α-position of various β-dicarbonyl compounds and 2-methylindanone is successfully achieved under conditions A). In case of 2-phenyl-1,3-indanone (IX), homocoupling is observed. -(MONGUCHI, Y.; TAKAHASHI, T.; IIDA, Y.; FUJIWARA, Y.; INAGAKI, Y.; MAEGAWA, T.; SAJIKI*, H.; Synlett 2008, 15, 2291-2294; Lab. Med. Chem., Gifu Pharm. Univ., Mitahora, Gifu 502, Japan; Eng.) -Mais 03-034