Aim - to evaluate the effectiveness of minilaparotomic access under intraoperative ultrasound navigation in the surgical treatment of liquid formations in the abdominal cavity and retroperitoneal space in comparison with the puncture-draining interventions under ultrasound guidance. Material and methods. The analysis covered the treatment of 77 patients with interventions for liquid formations of the abdominal cavity and retroperitoneal space using minimally invasive ultrasound-controlled technologies. Among them, 33 patients underwent puncture-draining interventions under ultrasound navigation (I group). Group II consisted of 44 patients with minilaparotomic surgery under intraoperative ultrasound guidance. Results. It is shown that minilaparotomic access under intraoperative ultrasound navigation allows performing one-step sanitation and drainage of abdominal structures of the abdominal cavity and retroperitoneal space, containing in the lumen not only liquid, but also dense necrotic tissues. Conclusion. The process is technically feasible in any surgical hospital, economically relevant, since it does not require the purchase of additional equipment. Application of this method can significantly reduce postoperative mortality.