The study aimed to unveil the effect of TK1 expression on the clinicopathological significance and prognosis in patients with lung cancer. Results & methodology: Studies for meta-analysis were selected according to a thorough literature search in databases (PubMed, EMBASE and Chinese databases). Ten studies containing 1393 lung cancer patients were investigated in our analysis. The TK1 overexpression was associated with poorer overall survival(OS) in lung cancer patients (hazard ratio = 1.881; 95% CI:1.318-2.684, Z = 3.48; p = 0.001). Furthermore, The TK1 expression is associated with the clinicopathological features of lung cancer patients (tumor type, age, lymph node metastasis, distant metastasis and tumor, node, metastasis [TNM] stages).  Discussion & conclusion: The TK1 expression might have a supportive implication in assessing biological behavior and prognosis of lung cancer patients.

Fiber coupling is difficult due to the uneven beam parameter product between the vertical and horizontal axes of semiconductor lasers. A beam shaping technique based on the combination of the internal total reflection and polarization surface of a stepped prism is proposed to achieve filling the dark area of the beam and polarization merging, as well as enabling the polarization plane to be multiplexed and the utilization rate of the polarization plane to be increased. The proposed technology can couple three groups of stacked array semiconductor lasers into a single fiber, in which the center diameter is 200 µm, and the numerical aperture is 0.22. The simulation results indicated that the output power of 1099 W and optical-optical conversion productivity of 85.8% were achieved.

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