Industrial peptide synthesis is generally carried out in batches and suffers both from the production of tremendous amounts of toxic waste and the difficulty to handle solids. In this study, peptide couplings were performed at the multigram scale by using reactive extrusion in a CMRfree (CMR = Carcinogenic, Mutagenic or Reprotoxic), solidtolerant, fast, efficient and epimerization-free manner, opening the way for intensified and continuous industrial production of peptides.

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