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A series of novel pyridazine derivatives incorporated with triazole, thiazolidine, imidazolidine, oxazine, and quinazoline moieties was synthesized by the reaction of [6-(4-phenoxyphenyl)pyridazin-3-yloxy]acetyl isothiocyanate with variety of nucleophilic reagents. The structures of all products were confirmed and characterized by the elemental analysis and spectroscopic studies (IR, MS, 1 H NMR). Also, the products were investigated for their antibacterial and antifungal activities and were compared with the standard drugs. Most of the synthesized compounds demonstrated potent to weak antimicrobial activity.

The applicability and synthetic potency of novel reagent, 2-aryl-1,1-dicyano-3-(phenylsulfo-nyl)propenes 3 to develop an expeditious convenient synthetic route of unique polyfunctionally substituted carbocyclic and heterocyclic sulfone systems is reported. Chemical and spec­troscopic evidence for the structures of the newly synthesized compounds are described. Some of the obtained compounds were tested for their antimicrobial activity

Reaction of N-{3-cyano-6-[4(5-oxo-2-phenylhydrazono-4,5-dihydroimidazol-1-yl)phenyl]-4-phenylpyridin- 2-yl}formimidic ethyl ester (3) and 3-[4-(3-amino-4-imino-5-phenyl-3,4-dihydropyrido[ 2,3-d]pyrimidin-7-yl)phenyl]-2-phenyl-5-phenylhydrazono-3,5-dihydroimidazol-4-one (4) with different reagents has been investigated and discussed. Some of the obtained compounds were tested for their antimicrobial activity.

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