The authors present the investigation results 49 patients with genital papillomas, leukoplakia, dysplasia and cancer of vulva and vagina. Based on the received data, one can suppose the essential role of HPV in the development of the lesions of vulva and vagina and reconsider the significance of the genotypes of high and low oncogenic risk in the development of non-malignant neoplasms, precancerous conditions and malignant growths of vulva and vagina.

In the article the main stages of carcinogenesis, caused by human papillomavirus, and also the basics of toxonomic classification, which is based on the phylogenetic analysis of viral DNA, are considered. The results of sequence-analysis of the L1 gene of HPV 16, detected in women living on the territory of the Republic of Belarus, have been presented.