Two field experiments were conducted during the two growing seasons of 2017 and 2018 at the Experimental Farm, Sakha Horticulture Research Station, Horticulture Research Institute, Egypt, to study the effect of irrigation intervals, magnetized water, organic and inorganic fertilizers and their combined interactions on yield and its components of Jerusalem artichoke (Helianthus tuberosus L.) plants. The results can be summarized as follows: As for irrigation intervals treatments, the treatment were obtained from Jerusalem artichoke plants irrigated every 20 days treatment gave the highest tuber yield (tubers weight /plant and ton/fed), water use efficiency, total carbohydrates. On the other hand, plants irrigated every 25 days recorded the highest values of TSS and tuber inulin in both seasons. Jerusalem artichoke plants irrigated with magnetized water gave the highest yield and its components (number of tubers/plant, tubers weight as ton/fed), water use efficiency as well as the highest values of total carbohydrates, TSS, inulin and tuber vitamin C content compared to the lowest ones resulted in control non-magnetized water treatment in both seasons. Also, the highest yield and its components were recorded when the plants were fertilized by 50% organic + 50% mineral in both seasons. Generally, it could be recommended that the Jerusalem artichoke plants were irrigated with magnetized water every 15 or 20 days and fertilized by 50% organic (FYM compost)+ 50% mineral (NK) produced high tubers yield, improved tuber quality (carbohydrates %, inulin, vitamin C and TSS) and water use efficiency under the conditions of this study.