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Adult male rats were treated with 1% and 5% Panax Ginseng in their diet for 60 days. Control rats were used. There was an increase in daily food consumption without an increase in body weight of treated animals. Rats that received 5% ginseng experienced a significant increase in blood testosterone level (p < 0.001). Prostate weight in the treated animals was significantly reduced as compared to the control animals.

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Adult male rats were injected intratesticularly with 3 mg and 6 mg zinc tannate (Kastrin) into each testis. Light microscopy and electron microscopy revealed that Kastrin is an effective irreversible chemical sterilant. Histological sections of testis indicated complete destruction of seminiferous tubules. Progeny testing of treated rats during a one-year period produced no pregnancy. No epididymitis or testicular teratoma were observed. Blood testosterone level of rats treated with 3 mg zinc tannate did not change significantly; however, in rats treated with 6 mg zinc tannate, blood testosterone level decreased significantly by 79% (p < 0.0001).