ABSTRACT. Studying the network of protein-protein interactions (PPIs) will provide valuable insights into the inner workings of cells. It is vitally important to develop an automated, high-throughput tool that efficiently predicts protein-protein interactions. This study proposes a new model for PPI prediction based on the concept of chaos game representation and the wavelet transform, which means that a considerable amount of sequence-order effects can be incorporated into a set of discrete numbers. The advantage of using chaos game representation and the wavelet transform to formulate the protein sequence is that it can more effectively reflect its overall sequenceorder characteristics than the conventional correlation factors. Using such a formulation frame to represent the protein sequences means that the random forest algorithm can be used to conduct the prediction. The results for a large-scale independent test dataset show that the proposed model can achieve an excellent performance with an accuracy value J.H. Jia et al. 11792©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 11791-11805 (2015) of about 0.86 and a geometry mean value of about 0.85. The model is therefore a useful supplementary tool for PPI predictions. The predictor used in this article is freely available at http://www.jci-bioinfo.cn/PPI.

Recent evidence have demonstrated that facial expressions could be a valid and important aspect for depression recognition. Although various works have been achieved in automatic depression recognition, it is a challenge to explore the inherent nuances of facial expressions that might reveal the underlying differences between depressed patients and healthy subjects under different stimuli. There is a lack of an undisturbed system that monitors depressive patients' mental states in various free-living scenarios, so this paper steps towards building a classification model where data collection, feature extraction, depression recognition and facial actions analysis are conducted to infer the differences of facial movements between depressive patients and healthy subjects. In this study, we firstly present a plan of dividing facial regions of interest to extract optical flow features of facial expressions for depression recognition. We then propose facial movements coefficients utilising discrete wavelet transformation. Specifically, Bayesian Networks equipped with construction of Pearson Correlation Coefficients based on discrete wavelet transformation is learnt, which allows for analysing movements of different facial regions. We evaluate our method on a clinically validated dataset of 30 depressed patients and 30 healthy control subjects, and experiments results obtained the accuracy and recall of 81.7 %, 96.7 %, respectively, outperforming other features for comparison. Most importantly, the Bayesian Networks we built on the coefficients under different stimuli may reveal some facial action patterns of depressed subjects, which have a potential to assist the automatic diagnosis of depression.

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