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Four hundred and fourteen cases of testicular germinal tumors treated at Roswell Park between 1920 and 1965 were reviewed. Seminoma was found to occur more often in older age groups than embryonal carcinoma or terato‐carcinoma. The incidence of prior trauma and history of maldescent were noted. The 2 most important prognostic factors were found to be histology and clinical stage. Other less significant factors were age, duration of symptoms, and positive chorionic gonadotrophin. The current different conventional modalities of therapy played only a subsidiary role in overall survival of testicular tumors.

Lactate dehydrogenase isoenzyme changes were studied in tissue specimens from patients with transitional cell cancer of the bladder. The ratio of LDH-V/I was determined in each specimen and compared to the histological grade of malignancy.The LDH-V/I ratio was found to be less than 1 in grades I and I1 and higher than 1 in grades I11 and IV, with an apparent higher value the higher the grade of malignancy. The significance of these elevated values and the possibility of future clinical applications are discussed.

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